Types of Heterochromia: Causes and Variations

Types of Heterochromia: Causes and Variations

Eye Health
By ZEELOOL|Jul 30, 2025

Have you ever seen someone with two different eye colors?

It looks magical, like a hidden story in their eyes. This is not a trick. This is a real condition. It has a name: heterochromia.

Heterochromia makes eyes truly unique. Some celebrities, like David Bowie and Mila Kunis, have it. People often find it beautiful. Some call it rare, others call it mysterious.

In this blog, you will learn about heterochromia. You will discover its types, learn what causes it, and uncover some interesting facts. We will also share styling tips for those who wear glasses.


What Is Heterochromia?

Heterochromia is when your eyes are two different colors. Sometimes, each eye has its own color. Sometimes one eye shows more than one shade. This change happens in the iris, the colored part of the eye.

It is rare in people. Heterochromia is present in fewer than 1% of the population. The CMAJ(a) explains that it affects fewer than 200,000 people in the U.S. This single trait is found in animals. You may have seen it in cats, dogs, or even horses. In them, it often happens naturally and does not cause concern.


Types of Heterochromia

There are three different types of heterochromia.

  • Complete Heterochromia: This is when each eye is an entirely different color. One may be green. The other may be brown. It is easy to notice. This is the rarest type.
  • Partial or Sectoral Heterochromia: In this condition, one eye exhibits two distinct colors. A slice or patch of a different color appears within the iris. It may look like a tiny mark or stripe.
  • Central Heterochromia: This one is subtle. The center of the iris, near the pupil, is a different color from the outer part. It creates a ring or halo effect. Some call it “sunburst eyes.”

Each type gives a unique look. It is like art made by nature.


A close-up of a woman's face with hands partially covering it, showcasing complete heterochromia with one blue eye and one brown eye.


Causes of Heterochromia

Heterochromia happens mainly due to melanin. Melanin is the pigment that gives color to the eyes, hair, and skin. More of it equals brown eyes; less pigment equals blue eyes. In fact, when that pigment is unevenly spread, you may get different colors in both eyes.


A collage of four close-up images showing different variations of heterochromia in various eye colors and patterns.


Genetics:

Many people are born with heterochromia. This is called congenital heterochromia. It often runs in families. In most cases, it causes no problems. It just makes the eyes look special.


Acquired Conditions:

Sometimes heterochromia happens later in life. This can happen from an accident, illness, or medicine.

Here are some causes:

  • Trauma to an Eye: A blow to the eye can damage the cells that produce color.
  • Inflammatory Processes: The iris is altered by diseases such as Uveitis or Fuchs' heterochromic iridocyclitis.
  • Medications: Certain glaucoma eye drops might darken the iris, especially prostaglandin analogs.
  • Diseases: Diseases like Horner's syndrome, Waardenburg syndrome, and eye tumors such as melanoma will have an influence on the eyes.
  • Pigment Dispersion Syndrome: Desquamation of pigment flakes occurs with movement inside the eye, hence affecting the change.


Mosaicism:

Sometimes, in early development, cells form with different genes. This leads to some cells making more melanin than others. The result is different shades in the eyes.


Neurofibromatosis:

This is a rare genetic condition. It can affect the nerves and skin. It sometimes causes changes in eye color, too.


Fun Facts and Cultural Significance About Heterochromia

Let’s talk about some famous individuals with unique eye colors. Kate Bosworth has complete heterochromia, meaning one of her eyes is blue while the other is hazel. She is best known for her role as Lois Lane in "Superman Returns." Speaking of Superman, the last portrayal is by Henry Cavill, who features two blue eyes; however, his left eye contains a patch of brown within the blue iris, which is referred to as partial heterochromia.

In various cultures, people believe that heterochromia signifies special gifts or talents. Some people view it as a sign of good luck, while others think it grants individuals the ability to see beyond the ordinary. Myths often associate heterochromia with mystery and magic. Regardless of the truth behind these beliefs, many agree that heterochromia is a rare and beautiful trait.


When to See a Doctor

If you have different colors in each eye, you oughtn't to panic; that might just be the way your body decided to express itself. Most people with heterochromia go on living their lives without much trouble. However, if you notice any sudden changes in color in your eyes, it's best to consult a doctor. Such sudden changes could indicate other medical problems.

Perhaps it’s an old injury resurfacing. Maybe it’s a reaction to medicine. Or perhaps it’s something that needs a closer look.

If you notice any new color changes, especially if they are accompanied by pain, blurry vision, or discomfort, don’t wait. Book a visit with your eye doctor. It’s always better to be sure than sorry. After all, your eyes tell more stories than you think.


Heterochromia and Eyeglasses Frames

Got heterochromia and wear glasses? That’s a style win waiting to happen.

With the right frames, you can make your eyes shine even more. Want something subtle? Try soft tones like clear, brown, or tortoiseshell. These shades let your natural eye colors do the talking. More of a bold soul? Try bright red, deep blue, or emerald green. Match the color of one eye, and boom, instant wow.


A young girl with heterochromia wearing glasses is smiling.


And guess what? You don’t even have to guess what looks good. ZEELOOL has tons of stylish glasses. We also offer a cool AR Try-On feature. You just try on frames virtually with your phone or computer. It’s easy and fun. And it saves you from buying something that doesn’t suit your face.

Glasses aren’t just for vision. They’re also for expression, especially when your eyes are already so one-of-a-kind.


Conclusion

Heterochromia might be rare, but it’s nothing short of amazing. It comes in three primary forms: complete, where both eyes are different; partial, where one eye has a splash of another color; and central, where you get a cool ring around the pupil.

Most of the time, heterochromia is a rare genetic gift. At other times, it may come from injury or illness. Either way, it deserves a little love and a little attention if something seems off.

And if you wear glasses? Use them to show off your eyes, not hide them. Let your frames add a little flair to your already standout look.

To beautiful eyes, beautiful stories, and the perfect pair of glasses! Please leave a comment with any stories about heterochromia you or someone you know might want to share. And if you're up for some frame fun, head over to ZEELOOL and get busy playing with your match!

Your eyes are already special. Let the world see them.


The Reference:

(a) CMAJ: https://pmc.ncbi.nlm.nih.gov/articles/PMC2518194/


Types of Heterochromia: Causes and Variations
ZEELOOL
ZEELOOL
Eyewear Brand
Hi, here is ZEELOOL, your go-to for eyewear. I'm not just an eyewear brand, I'm good at everything in the eyewear industry. I can help you keep updated on the latest trends, provide my suggestions on perfect fits for outfits and scenarios. For different styles of glasses, I'm able to introduce the functions, materials and design features, but also share expertise on eye health and lens knowledge. I would like to provide you with valuable information by sharing the real reviews and experiences collected.
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